Outcomes of limited stage primary bone diffuse large B-cell lymphoma in the rituximab era: a multicenter, retrospective study

Outcomes of limited stage primary bone diffuse large B-cell lymphoma in the rituximab era: a multicenter, retrospective study

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Primary bone diffuse large B-cell lymphoma is a rare variant of extranodal non-Hodgkin lymphoma historically treated with induction chemotherapy followed by consolidative radiation therapy (RT).It remains unknown whether RT confers additional lorenametaute.com benefit following rituximab-based chemoimmunotherapy (CIT) induction in patients with limited stage disease.We conducted a multicenter, retrospective analysis of patients treated between 2005 and 2019 using rituximab-based CIT regimens with or without consolidative RT to discern whether consolidative RT adds benefit in patients with stage I-II disease that could be encompassed in one radiation field.

A total of 112 patients were included: 78 received CIT and radiation (RT group), and 34 received CIT alone (no RT group).The overall survival at 10 years was 77.9% in the RT group and 89.

0% in the no RT group (P=0.42).The relapse-free survival at 10 years was 73.

5% sukrensi.com in the RT group and 80.3% in the no RT group (P=0.88).

Neither improved overall survival nor relapse-free survival was associated with the addition of consolidative RT.Subgroup analysis of patients only achieving a partial response after CIT suggests that these patients may benefit from consolidative RT.